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diagnosis abnormal aptt coagulation hematology hepatology prolonged aflp alkaline alp disease elevation hellp hepatitis icp obstetrics phosphatase pregnancy
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... • Reduced liver ... • Massive hemorrhage
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
imaging: Hepatic ... extensive necrosis and hemorrhage ... often <5 mg/dL, higher ... obstetrics #hepatitis #comparison ... #differential #
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... Massive hemorrhage ... #diagnosis #differential
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Diagnosis Algorithm ... phosphatase sources: - Highest ... • Bone • Liver ... Intestine - Other causes ... elevation DDX of Hepatic
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