6 results
Fungal biomarkers
Beta-d-glucan
Aspergillus galactomannan

By Dr. Sara Dong @swinndong via Febrile [febrilepodcast.com]

#ID  #Infectious Diseases  #Infections
#Differential #Ddx
Beta-d-glucan Aspergillus ... febrilepodcast.com] #ID ... #Infections #Differential ... #Ddx #Diagnosis ... Fungal #Fungi #BDG
ID Ddx: Diarrhea in a transplant recipient
- Bacterial: C.diff, Campy, Salmonella, Aeromonas, E.coli
- Viral: CMV, noro,
ID Ddx: Diarrhea ... #Infections #Differential ... #Ddx #Diagnosis ... Diarrhea #Transplant #TxID ... #SOT #Causes
Invasive Aspergillus (IA) - Diagnosis and Management
Aspergillus is ubiquitous in nature. Most invasive infections are caused
allogeneic HSCT, SOT ... Galactomannan sensitivity ... Penicillium • BDG ... associated with low sensitivity ... angle branching • Ddx
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
Specificity: - Serum BDG ... invasive fungal infection ... increase BDG!) ... differentiate colonization ... setting of GVHD) ID
Timeline of infections after solid organ transplantation can roughly be broken up into three time periods:
febrilepodcast.com] #ID ... #Infections #Differential ... #Ddx #Diagnosis ... #Transplant #TxID ... #SOT #Comparison
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives
1,3-Beta-D-Glucan
 • Cell wall component of many fungi
Galactomannan Testing Sensitivity ... TBDG), Use of cellulose ... surfaces, Albumin, Infections ... Spec 81% for dx ... differentiate colonization