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diagnosis betadglucan galactomannan laboratory antibiotic aspergillus bcx biomarkers bloodculture comparison contaminant contaminants ddx dehydrogenase elevated failure falsepositives lactate ldh microbiology
Blood culture contaminants Grouped by gram negative vs gram positive vs other as well as never/maybe/probably Some additional
other as well as never ... febrilepodcast] #ID ... #Infectious Diseases ... #Infections #Microbiology ... #Micro #Differential
Causes of Antibiotic Failure - Differential Diagnosis Framework Diagnosis: • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
Diagnosis: • Non-Infectious ... bacteria: Viral, Fungal ... take 48 hrs for infections ... SJS, DIHS, drug fever ... rxn), Secondary infection
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) ... surfaces - Infections ... differentiate colonization ... non-neutropenic pts, SOT ... setting of GVHD) ID
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
component of many fungi ... surfaces, Albumin, Infections ... differentiate colonization ... post-2010 almost never ... GVHD), Certain blood
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... deficiency of red blood ... • Toxins • Infection ... myocarditis, rheumatic fever ... immunoglobulin), not
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