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diagnosis adrenal insufficiency differential ai hemophagocytic hlh immunecompromised immunocompromised laboratory lymphohistiocytosis management rheumatology stimulation summary test testing treatment workup
Causes of Adrenal Insufficiency - Differential Diagnosis Algorithm ACTH-Dependent (Secondary): • Pituitary Dysfunction • Hypothalamic Dysfunction ACTH-Independent (Primary):
Causes of Adrenal ... ACTH-Dependent ... : • Pituitary Dysfunction ... ACTH-Independent ... #Causes #endocrinology
Adrenal Insufficiency Diagnosis Algorithm - Evaluation of HPA Axis Response to ACTH Early am cortisol < 3
Insufficiency Diagnosis Algorithm ... - Evaluation of ... unclear (often the case ... Insufficiency #Diagnosis #Algorithm ... #Test #Endocrinology
Primary Adrenal Insufficiency: • ACTH stimulation test - Synthetic ACTH does not stimulate cortisol secretion because
Insufficiency: • ACTH ... secretion because the dysfunctional ... aldosterone - Low in cases ... Insufficiency #Evaluation ... diagnosis #testing #endocrinology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... , Hb), Hepatic dysfunction ... Drugs, Unknown cause ... inhibitors under evaluation ... treatment #summary #rheumatology
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Differential Diagnosis Algorithm ... or Neutrophil Dysfunction ... Infection #Fever ... #Causes #Hematology
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