13 results
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
Agents - Dr. ... Kayexelate #Comparison #Table ... #Pharmacology # ... Patiromer #HyperKalemia ... #Nephrology #Agents
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... #differential #diagnosis ... pathophysiology #pharmacology ... #potassium #medications ... #druginduced
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic Agents ... Subclass, Drug ... #Pharmacology # ... summary #table # ... nephrology
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Agents to Treat ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison
Drug Induced Kidney Injury
 • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy
 • Osmotic
Mannitol, Contrast agents ... @kdjhaveri #DrugInduced ... #differential #diagnosis ... #algorithm #nephrology ... #Medications
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Diagnosis Framework ... reactions Common Drugs ... Medications 2. ... #causes #potassium ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Diagnosis Framework ... reactions Common Drugs ... • Recent IV potassium ... Medications 2. ... #high #nephrology
Numerous drugs taken by elderly persons can affect water balance by direct action on the kidney
Numerous drugs taken ... on the kidney (Table ... #Diagnosis #Pharmacology ... #Hyponatremia #Medications ... #DrugInduced #List
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
- Differential Diagnosis ... - Toxins - Drugs ... Monitor potassium ... per day until stable ... causes #treatment #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... Etiology: • Medications ... Elimination (see Table ... #Treatment #potassium ... #nephrology #K