12 results
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
- Local and systemic ... antigen, leading to complement ... Complement activation ... arthritis, and systemic ... #Classification
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Hypersensitivity: Summary Type ... conjunctivitis Type ... Graves' Disease Type ... complexes • Ex: Systemic ... #Types #Classification
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis, type ... 1 (50%-80%), type ... glomerulonephritis (>90%) S - Systemic ... #Low #Complement
Angioedema - Classification Diagnosis and Treatment
Types of Angioedema:
 • Acute allergic angioedema - Usually occurs with
Angioedema - Classification ... and Treatment Types ... Acquired C1 inhibitor deficiency ... #Angioedema #Classification ... #Types #Diagnosis
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
antigens, leading to complement ... they activate complement ... glomerulonephritis, Systemic ... #allergy #table ... #classification
Complement 1 esterase inhibitor (C1-INH) Deficiency Testing Algorithm
INDICATIONS FOR TESTING:
 • Recurrent angioedema (without urticaria)
 •
Complement 1 esterase ... inhibitor (C1-INH) Deficiency ... Testing Algorithm ... #Testing #Algorithm ... #allergy #diagnosis
Penicillin Allergy Pathway for Antibiotic Prescription in Patients With Penicillin Allergy
Mild Reaction - Itching, Minor rash
Maculopapular rash (mild type ... Use carbapenem Type ... Type II-IV HSR ... rash eosinophilia systemic ... #Prescription #algorithm
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Types: • Type ... • Low serum C4 complement ... disorder (e.g. systemic ... #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... central nervous system ... against MPO • Complement ... #rheumatology #classification
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
are listed as Type ... malignancy, or thiamine deficiency ... of Circulatory System ... effect - Thiamine deficiency ... #typeb #classification