13 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... , type 1 (50%-80% ... ), type II (80-90% ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... Allergen-specific lgE causes ... Post-streptococcal glomerulonephritis ... #allergy #table ... #classification
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... Post-streptococcal glomerulonephritis ... #Classification ... Diagnosis #Reactions #Table
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... pathophysiologic causes ... staining): • Low Complement ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Skin ulcers - Glomerulonephritis ... Cryoglobulins Cause ... • Low serum C4 complement ... #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
Hypokalemia - Differential Diagnosis
Poor Intake 
 - Starvation
 - Anorexia
GI Losses 
 - Vomiting / NG
tubular acidosis (Types ... and 2, but not type ... Low #Potassium #Table ... #Classification ... #Causes
Comprehensive pathogenesis of IgA Nephropathy (i.e Berger’s Disease). 

IgA Nephropathy is the most common cause of
the most common cause ... of Glomerulonephritis ... - What type of Hypersensitivity ... Relationship of complement ... AcuteGlomerulonephritis #Glomerulonephritis
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
or alternative complement ... infections are common causes ... cryoglobulinemias (types ... workup #diagnosis #glomerulonephritis
Type 2 Diabetes - Screening, Diagnosis and Management Algorithm
Lifestyle  Modifications (Diet and Exercise) -> Start
Type 2 Diabetes ... and Management Algorithm ... • Secondary Causes ... Targets #Management #algorithm ... #DM2 #DMII #Classification