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diagnosis differential rheumatology allergy vasculitis hypersensitivity management glomerular glomerulonephritis nephrology nephrotic table testing workup allergic angioedema champs clinicopathology comparison cryoglobulins
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Mnemonic C - Cryoglobulinemia ... glomerulonephritis, type ... 1 (50%-80%), type ... #Low #Complement
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Types: • Type ... • Low serum C4 complement ... #classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
hypersensitivity reactions ... Allergen-specific lgE causes ... antigens, leading to complement ... they activate complement ... #table #classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity Types ... antigen, leading to complement ... Complement activation ... #Classification ... Allergy #Diagnosis #Reactions
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Lupus Nephritis, Cryoglobulinemia ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Hemolysis Classification - Intrinsic and Extrinsic Causes Commentary: Another way to think of immune hemolysis would be
Hemolysis Classification ... and Extrinsic Causes ... hemolytic transfusion reactions ... #Hemolysis #Classification ... #Algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... ANCA +MPO) • Cryoglobulinemic ... disease, drug reactions ... against MPO • Complement ... #rheumatology #classification
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
Definitions • Type ... cell surfaces causes ... • Type Ill - ... exposure to allergen causes ... #Types #Classification
Angioedema - Classification Diagnosis and Treatment Types of Angioedema: • Acute allergic angioedema - Usually occurs with
Angioedema - Classification ... and Treatment Types ... Non-allergic drug reaction ... cell-mediated in > 90% of cases ... #Types #Diagnosis
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
or alternative complement ... infections are common causes ... factor - Screen for cryoglobulinemias ... (types 2 and 3)
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