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diagnosis hypersensitivity rheumatology differential table vasculitis allergic antibiotics champs comparison cryoglobulinemia cryoglobulins definitions erythematosus hematology low management mnemonic pathophysiology pathway
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
complexes • Ex: Systemic ... Lupus Erythematosus ... Dermatitis (ie. reaction ... #Allergic #Reactions ... #Types #Classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... Complement activation ... lupus erythematosus ... #Classification ... #Diagnosis #Reactions
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
they activate complement ... glomerulonephritis, Systemic ... lupus erythematosus ... #types #allergy ... #table #classification
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... 1 (50%-80%), type ... glomerulonephritis (>90%) S - Systemic ... Lupus Erythematosus ... #Low #Complement
Penicillin Allergy Pathway for Antibiotic Prescription in Patients With Penicillin Allergy Mild Reaction - Itching, Minor rash
Mild Reaction ... urticaria OR Unknown reaction ... Type II-IV HSR ... rash eosinophilia systemic ... #Prescription #algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • Low serum C4 complement ... disorder (e.g. systemic ... lupus erythematosus ... #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... lupus erythematosus ... disease, drug reactions ... against MPO • Complement ... #rheumatology #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... Kikuchi disease • Type-I ... RNP antibodies, Complement
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