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diagnosis rheumatology allergy hypersensitivity reactions table comparison cryoglobulinemia cryoglobulins differential erythematosus igg4 management pathophysiology sle systemic vasculitides
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... Types: • Type ... • Low serum C4 complement ... (e.g. systemic lupus ... #classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
cellular antigen, leading ... to complement activation ... Complement activation ... , and systemic lupus ... #Classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Urticaria and hypocomplementemia ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... #rheumatology #classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
cell antigens, leading ... to complement activation ... they activate complement ... glomerulonephritis, Systemic lupus ... allergy #table #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... Kikuchi disease • Type-I ... mild cognitive dysfunction ... RNP antibodies, Complement
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... • Pancreas: Type ... aortitis, mimics vasculitis ... - ↑ IgE, ↓ complement ... • Classification
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