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diagnosis differential rheumatology allergy hypersensitivity management reactions pathophysiology table vasculitis acidosis addisons adrenal allergic comparison complications cryoglobulinemia cryoglobulins definitions diabeticfoot
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
cellular antigen, leading ... to complement activation ... Complement activation ... I diabetes mellitus ... #Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Allergen-specific lgE causes ... antigens, leading ... to complement activation ... they activate complement ... allergy #table #classification
Classification of Diabetes Insipidus Central or neurogenic diabetes insipidus: - Congenital - Structural malformations affecting the hypothalamus
Classification of ... uropathy, Metabolic causes ... hypercalcemia), Sickle cell ... #Classification ... #Types #Nephrology
Diabetic Foot: Pathogenesis and clinical findings • Polyol Pathway - Excess glucose enters Polyol pathway ->
accumulates in cells ... essential for cell ... Glycosylation - AGE cause ... increasing cytogenetic dysfunction ... in inopportune loading
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... • They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... #classification
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
Definitions • Type ... degranulation, leading ... surfaces causes ... exposure to allergen causes ... #Classification
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... protein receptor type ... activin A receptor type ... pulmonary Langerhans cell ... #Differential #Causes
Primary Adrenal Insufficiency Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
cancer • Renal cell ... Hypoparathyroidism - Type ... 1 diabetes mellitus ... Symptoms: • Salt craving ... NAGMA from RTA type
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... e.g., uptake by cells ... B1: - Diabetes ... #typea #typeb # ... classification
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... progressive organ dysfunction ... • Pancreas: Type ... - ↑ IgE, ↓ complement ... • Classification
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