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diagnosis rheumatology differential table allergy hypersensitivity management reactions vasculitis causes compared cryoglobulinemia cryoglobulins dermatology erythemas erythematosus histiocytosis hypertension igg4 langerhans
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... cellular antigen, leading ... to complement activation ... Complement activation ... #Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
antigens, leading ... to complement activation ... glomerulonephritis, Systemic ... allergy #table #classification ... #comparison
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... protein receptor type ... activin A receptor type ... dysfunction ... pulmonary Langerhans cell
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... , leading to the ... • Low serum C4 complement ... disorder (e.g. systemic ... #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... episcleritis as well ... against MPO • Complement ... #rheumatology #classification
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... progressive organ dysfunction ... • Pancreas: Type ... - ↑ IgE, ↓ complement ... • Classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... Kikuchi disease • Type-I ... mild cognitive dysfunction ... : • Chronic B-cell
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
form of delayed-type ... (cutaneous or systemic ... to have a "wood-grain ... multiforme • Acute systemic ... PrathitKulkarni #Erythemas #comparison
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
virtually any organ system ... , a type of dendritic ... various tissues, leading ... • Endocrine Dysfunction ... Single-System (Low
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