19 results
Overview of the Complement System - Classical and Alternative Pathways

by Dr.Grace Leo @gracie_leo

#Complement #System #Classical #Alternative
Overview of the Complement ... System - Classical ... and Alternative ... #System #Classical ... #Pathophysiology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis (>90%) S - Systemic ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... HLA-DR3 genes, complement ... Multiple immune system ... IL-6, IL-10 #Systemic ... Erythematosus #SLE #Pathophysiology
Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... System: opsonize ... activation of complement ... system • Cell-mediated ... #Inflammation #pathophysiology
Flowchart of the function of the renin-angiotensin aldosterone system (RAAS)

#renin #angiotensin #aldosterone #system #RAAS #system #algorithm
renin-angiotensin aldosterone system ... #aldosterone #system ... #RAAS #system # ... algorithm #pathophysiology
A System for Vasculitides 

#Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... #Vessel #Size #Classification ... #Differential #Algorithm
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... -> Classical, alternative ... susceptibility to systemic ... #pathophysiology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
- Local and systemic ... Complement activation ... arthritis, and systemic ... Hypersensitivity #Types #Classification ... #Pathophysiology
Bleeding and Bruising - Differential Diagnosis Algorithm
 • Vascular System Defect - Congenital vs Acquired
 •
Differential Diagnosis Algorithm ... • Vascular System ... Differential #Diagnosis #Algorithm ... #pathophysiology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
central nervous system ... Differential Diagnosis: Systemic ... diseases, such as systemic ... Presentation - Systemic ... against MPO • Complement