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diagnosis rheumatology differential hypersensitivity hypersensitivityreaction immunology reactions hematology management table vasculitis allergic antibiotics champs comparison cryoglobulinemia cryoglobulins definitions disorders erythematosus
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... Complement activation ... arthritis, and systemic ... #Classification ... #Pathophysiology
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Hypersensitivity: Summary Type ... conjunctivitis Type ... Graves' Disease Type ... complexes • Ex: Systemic ... #Types #Classification
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis, type ... 1 (50%-80%), type ... glomerulonephritis (>90%) S - Systemic ... #Low #Complement
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
Type I Hypersensitivity ... Patient's immune system ... Anaphylaxis #TypeI ... #Type1 #HypersensitivityReaction ... #pathophysiology
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
antigens, leading to complement ... they activate complement ... glomerulonephritis, Systemic ... #allergy #table ... #classification
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity ... the cause: • Systemic ... sickness #TypeIII #Type3 ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
Type II Hypersensitivity ... activates the complement ... cell surfaces #Type2 ... #Allergy #Immunology ... #pathophysiology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Types: • Type ... • Low serum C4 complement ... disorder (e.g. systemic ... #classification
Penicillin Allergy Pathway for Antibiotic Prescription in Patients With Penicillin Allergy Mild Reaction - Itching, Minor rash
Maculopapular rash (mild type ... Use carbapenem Type ... Type II-IV HSR ... rash eosinophilia systemic ... #Prescription #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... central nervous system ... against MPO • Complement ... #rheumatology #classification
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