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diagnosis rheumatology differential disease hematology laboratory management nephrology allergy causes comparison glomerular hypersensitivity lupus nephrotic potassium reactions sle vasculitis agglutinin
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis, type ... 1 (50%-80%), type ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Hypokalemia - Differential Diagnosis Poor Intake - Starvation - Anorexia GI Losses - Vomiting / NG
and 2, but not type ... 4) - Salt wasting ... Differential #Diagnosis #Low ... #Potassium #Table ... #Classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity Types ... antigen, leading to complement ... Complement activation ... #Classification ... Diagnosis #Reactions #Table
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... antigens, leading to complement ... they activate complement ... #allergy #table ... #classification
Hypomagnesemia - Etiologies by Mechanism Decreased GI Uptake - Poor dietary intake (particularly common in alcoholics)
Familial renal Mg wasting ... Differential #Diagnosis #Low ... #Magnesium #Table ... #Classification ... #Causes #Workup
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Types: • Type ... • Type III Often ... factor level • Low ... serum C4 complement ... #classification
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... in monitoring low-level ... or alternative complement ... cryoglobulinemias (types ... #workup #diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... in >90% - Low ... complement - Rare ... complement - 50 ... sle #comparison #table
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease 3 Types ... originate from a low-grade ... Positive Coombs testing ... post infectious setting ... temperatures by fixing complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... #rheumatology #classification
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