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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... (Granulomatous disease ... atherosclerotic disease ... against MPO • Complement
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Causes of ileitis beyond Crohn’s disease and infections include systemic disorders -spondyloarthropathies, vasculitides, ischemia, and amyloidosis
beyond Crohn’s disease ... spondyloarthropathies, vasculitides ... See below for table ... helpful paper complements ... #Differential #Table
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... reaction, Haemolytic disease ... they activate complement ... types #allergy #table ... classification #comparison
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
90% - Low complement ... 80% - Low complement ... Evolution: Chronic disease ... druginduced #lupus #sle #comparison ... #table #rheumatology
Erythemas Summarized
Erythema ab igne
 • A dermatosis that results from repeated exposure to heat (fires, heating
early localized disease ... of necrotizing vasculitis ... called "Bazin's disease ... PrathitKulkarni #Erythemas #comparison ... #table #differential
Diets and Inflammatory Bowel Disease (IBD)
Diet affects IBD by 3 mechanisms
1. Microbiome ( ↓ diversity)
2. Mucosal
Inflammatory Bowel Disease ... • Nutrition as complement ... balanced, nutritious Table ... IBD #Nutrition #comparison ... #table #management