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diagnosis rheumatology allergy hypersensitivity reactions vasculitis cryoglobulinemia cryoglobulins differential druginduced erythematosus management pathophysiology vasculitides
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... Complement activation ... lupus erythematosus ... #Classification ... Diagnosis #Reactions #Table
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... glomerulonephritis, Systemic ... lupus erythematosus ... #classification ... #comparison
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
90% - Low complement ... months to years) Systemic ... 80% - Low complement ... #sle #comparison ... #table #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • Low serum C4 complement ... lupus erythematosus ... (SLE), rheumatoid ... #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... Kikuchi disease • Type-I ... #Systemic #Lupus
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... lupus erythematosus ... against MPO • Complement ... vasculitis, and SLE ... #rheumatology #classification
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