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diagnosis rheumatology differential hematology vasculitis arthritis champs classification deficiency disease erythematosus glomerulonephritis laboratory mnemonic progressive rapidly rheumatic rheumatoid rpgn sle
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... S - Systemic Lupus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Complement Deficiency Testing Algorithm • Normal CH50 and AH50 AND High suspicion for complement deficiency •
Complement Deficiency ... Testing Algorithm ... deficiency • Low ... #Deficiency #Testing ... #Algorithm #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... complements and ... pneumonitis • Diffuse ... enteropathy, and diffuse ... , lymphopenia, low
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Urticaria and hypocomplementemia ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... (Low levels mixed
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... - CCP antibody testing ... Screening Tests for Diffuse ... Additional Tests for Diffuse ... chest wall, and low
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