5 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... , type 1 (50%-80% ... ), type II (80-90% ... S - Systemic Lupus ... #Low #Complement
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... (Low levels mixed
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Skin ulcers - Glomerulonephritis ... factor level • Low ... serum C4 complement ... (e.g. systemic lupus
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
in monitoring low-level ... or alternative complement ... infections are common causes ... cryoglobulinemias (types ... workup #diagnosis #glomerulonephritis