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diagnosis differential rheumatology hematology vasculitis workup classification glomerular glomerulonephritis laboratory nephrology nephrotic agglutinin aggregometry anemia arthritis causes champs clinicopathology cryoglobulinemia
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... 1 (50%-80%), type ... S - Systemic Lupus ... #Low #Complement
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Disease 3 Types ... originate from a low-grade ... Positive Coombs testing ... post infectious setting ... temperatures by fixing complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... involvement: Anti-GBM Disease ... differential #diagnosis #algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... Types: • Type ... factor level • Low ... serum C4 complement ... (e.g. systemic lupus
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Urticaria and hypocomplementemia ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... (Low levels mixed
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... complements and ... • Type-I Interferonopathies ... , lymphopenia, low ... RNP antibodies, Complement
Factors that May Affect Fetal Oxygenation - Differential Diagnosis Algorithm Excessive Uterine Activity: • Hyperstimulation • Placental
Differential Diagnosis Algorithm ... • Respiratory disease ... Uterine Blood Flow ... Vasculopathy (SLE, Type ... Differential #Diagnosis #Algorithm
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
• This pattern could ... (either severe Type ... 1 or Type 3) — ... Von Willebrand Disease ... considered first-line testing
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Ischemic heart disease ... event, follow ACC algorithm ... Risk Stratify Type ... Orthopedic • Low ... What is the type
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... for glomerular disease ... in monitoring low-level ... or alternative complement ... cryoglobulinemias (types
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