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diagnosis differential rheumatology vasculitis champs cryoglobulinemia cryoglobulins erythematosus high hyperkalemia low lupus management mnemonic polycythemia potassium sjogrens syndrome vasculitides workup
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... 1 (50%-80%), type ... glomerulonephritis (>90%) S - Systemic ... #Low #Complement ... #differential #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... Kikuchi disease • Type-I ... the context of primary
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Urticaria and hypocomplementemia ... against MPO • Complement ... vasculitis, and SLE ... #classification
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Cytopenia: 2% • Hypocomplementemia ... • Can cause TYPE ... IV RTA, TYPE I ... Nephrogenic DI Hematologic
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... with GCA or as primary ... Rash, arthritis Primary ... tract, and often causes ... Vasculitis) • Hypocomplementemic
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... frequently affected systems ... Better call hematology ... some time, let’s see ... up EPO levels Primary
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
Causes of Hyperkalemia ... erythematosus (SLE ... Primary adrenal ... High #Potassium #Classification ... #Causes
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