Hypocomplementemia complement table algorithm vasculitis huv testing cold classification anemia

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Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cryoglobulins (Vasculitic ... • Symptoms of anemia ... Positive Coombs testing ... Mycoplasma, EBV, HIV ... temperatures by fixing complement

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia ... Agglutination - Cold ... DIC, TTP, HELLP, HUS ... cardiac valve, vasculitis ... workup #hematology #testing

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