Hypocomplementemia complement table algorithm vasculitis huv testing fever classification cold

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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

Urticaria and hypocomplementemia ... Coronary arteries - Fever ... : • Fevers • ... against MPO • Complement ... #rheumatology #classification

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cryoglobulins (Vasculitic ... Positive Coombs testing ... Mycoplasma, EBV, HIV ... temperatures by fixing complement ... Symptoms: High fevers

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Agglutination - Cold ... DIC, TTP, HELLP, HUS ... cardiac valve, vasculitis ... bartonella (oroya fever ... workup #hematology #testing

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