13 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... Membranoproliferative glomerulonephritis ... Post/pauci immune glomerulonephritis ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
RPGN has three primary ... staining): • Low ... Complement: Post-strep ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... #rheumatology #classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... they activate complement ... Post-streptococcal glomerulonephritis ... types #allergy #table ... #classification
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... Post-streptococcal glomerulonephritis ... Hypersensitivity #Types #Classification ... Diagnosis #Reactions #Table
Hypokalemia - Differential Diagnosis
Poor Intake 
 - Starvation
 - Anorexia
GI Losses 
 - Vomiting / NG
Ureterosigmoidostomy Urinary ... Differential #Diagnosis #Low ... #Potassium #Table ... #Classification
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
inhibitors - Primary ... Differential #Diagnosis #Low ... #Magnesium #Table ... #Classification
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... factor level • Low ... serum C4 complement ... diagnosis #types #classification
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... can be high or low ... water intake (Primary ... polydipsia), Low ... differential #diagnosis #table
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... complements and ... Skin Disease Classification ... the context of primary ... , lymphopenia, low