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diagnosis rheumatology differential nephrology glomerulonephritis nephrotic workup cryoglobulinemia cryoglobulins erythematosus initial lupus nephritic nephritis progressive pulmonary rapidly renal rpgn sle
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Skin, glomeruli ... Urticaria and hypocomplementemia ... : - Kidneys: glomerular ... against MPO • Complement ... #rheumatology #classification
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
vasculitis (Eosinophilic ... vasculitis (IgA-associated ... vasculitis, Behcet ... sclerosis • Anti-Glomerular ... testing: anti-ANCA
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... disease 24- ... or alternative complement ... disease. ... ANCA-related vasculitis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
atherosclerotic disease ... most important diseases ... • Kidneys: Non-glomerular ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... disease. 8) ANA ... vasculitis. 10 ... #glomerular #disease
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... • Low serum C4 complement ... DDX: • ANCA (Antineutrophil ... • Vasculitis ... diagnosis #types #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Classification: ... vasculitis, rheumatoid ... • Mesenteric vasculitis ... RNP antibodies, Complement
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