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diagnosis rheumatology allergy differential disease glomerular hypersensitivity management nephrology nephrotic reactions table testing workup agglutinin anemia cold comparison cryoglobulinemia cryoglobulins
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
and often causes arthritis ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Types: • Type ... arthralgia, and arthritis ... • Low serum C4 complement ... SLE), rheumatoid arthritis ... #classification
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
affects large arteries ... affects medium arteries ... rarely affects arteries ... can affect any type ... Medium #Large #Classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity Types ... antigen, leading to complement ... Complement activation ... glomerulonephritis, rheumatoid arthritis ... #Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of types ... antigens, leading to complement ... they activate complement ... Examples: Rheumatoid arthritis ... allergy #table #classification
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
for monoclonal gammopathy ... of monoclonal gammopathy ... or alternative complement ... for ANCA-related vasculitis ... cryoglobulinemias (types
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
or alternative complement ... for monoclonal gammopathy ... of monoclonal gammopathy ... for ANCA-related vasculitis ... cryoglobulinemias (types
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... ANCA-associated vasculitis ... Kikuchi disease • Type-I ... RNP antibodies, Complement
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease 3 Types ... Cryoglobulins (Vasculitic ... IgM monoclonal gammopathy ... temperatures by fixing complement
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
• Pancreas: Type ... aortitis, mimics vasculitis ... - ↑ IgE, ↓ complement ... • Classification
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