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diagnosis rheumatology allergy differential hypersensitivity reactions comparison cryoglobulinemia cryoglobulins erythematosus lupus management medium pathophysiology sjogrens sle small syndrome systemic vasculitides
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
Large vessel vasculitis ... affects large arteries ... affects medium arteries ... can affect any type ... #Classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Urticaria and hypocomplementemia ... LARGE VESSEL ... Vessel Size: • Large ... against MPO • Complement ... #rheumatology #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Types: • Type ... arthralgia, and arthritis ... • Low serum C4 complement ... SLE), rheumatoid arthritis ... #classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... glomerulonephritis, rheumatoid arthritis ... #Classification ... Diagnosis #Reactions #Table
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... they activate complement ... Examples: Rheumatoid arthritis ... #allergy #table ... #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... Kikuchi disease • Type-I ... the small and large ... RNP antibodies, Complement
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... Arthralgia and Arthritis ... cell lymphoma • Large
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