Hypocomplementemia complement vasculitis algorithm testing cold copd function pediatrics agglutinin

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Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cold Agglutinin ... Cold Agglutinins ... Cryoglobulins (Vasculitic ... Positive Coombs testing ... temperatures by fixing complement

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Differential Diagnosis Algorithm ... Agglutination - Cold ... agglutinins disease ... cardiac valve, vasculitis ... workup #hematology #testing

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