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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Urticaria and hypocomplementemia ... Coronary arteries - Fever ... mucositis - Rash ... : • Fevers • ... against MPO • Complement
ID Approach to Fever and Rash - Diagnostic Algorithm
Central Maculopapular (most common):
Measles, Parvovirus 819 / EBV,
and Rash - Diagnostic ... Algorithm Central ... Parvovirus B19 (PPGSS), Vasculitis ... (Pseudomonas, mold ... #Rash #Febrile
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH 

These rashes can be especially challenging and are
associated with devastating differential
petechiae/purpura with fever ... require emergent evaluation ... petechiae/purpura with fever ... petechial or purpuric rash ... Purpural #Purpuric #Rash
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Positive Coombs testing ... post infectious setting ... temperatures by fixing complement ... Symptoms: High fevers
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Agglutination - Cold ... cardiac valve, vasculitis ... bartonella (oroya fever ... workup #hematology #testing
Preoperative Risk Evaluation

Major Pre-Op Questions:
1. Does the patient have any modifiable risk factors that could be
Preoperative Risk Evaluation ... or family - Ever ... event, follow ACC algorithm ... surgery Stress Testing ... perioperative #Risk #Evaluation
Evaluation of suspected incomplete Kawasaki Disease

1. AHA consensus recommendations
2. Infants ≤6 months old on day ≥7
Evaluation of suspected ... Infants ≤6 months old ... on day ≥7 of fever ... should undergo lab testing ... within 10 d of fever