Hypocomplementemia complement vasculitis algorithm workup testing anemia initial cold differential

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Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia ... Agglutination - Cold ... cardiac valve, vasculitis ... #workup #hematology ... #testing

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cryoglobulins (Vasculitic ... • Symptoms of anemia ... Positive Coombs testing ... younger pts) Differential ... temperatures by fixing complement

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