Hypocomplementemia complement vasculitis classification glomerular initial testing differential

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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

- Differential ... - Skin, glomeruli ... : - Kidneys: glomerular ... against MPO • Complement ... #rheumatology #classification

Vasculitis - Break down based on vessel size
Distribution of vessel involvement by large vessel vasculitis,

Vasculitis - Break ... by large vessel vasculitis ... Anti-GBM = anti–glomerular ... #Rheumatology #Differential ... Medium #Large #Classification

Recommended initial testing for patients being evaluated for glomerular disease

24-hour urine collection - Quantify proteinuria.

Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.

Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):

symptomatology Differential ... ANCA-positive vasculitis ... sclerosis • Anti-Glomerular ... Disease-specific testing ... Renal #Syndrome #differential

Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,

Vasculitis - Differential ... Differential Diagnosis ... • Kidneys: Non-glomerular ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cryoglobulins (Vasculitic ... Positive Coombs testing ... post infectious setting ... younger pts) Differential ... temperatures by fixing complement

Shock Overview
A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting

develop in the setting ... While initially ... EmmGeezee #Shock #Classification ... #criticalcare #differential ... #causes #classification

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

anti-Smith Ab, low complements ... Skin Disease Classification ... permanent alopecia Differential ... ANCA-associated vasculitis ... RNP antibodies, Complement

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