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diagnosis rheumatology differential large medium cryoglobulinemia cryoglobulins ddxof erythematosus glomerulonephritis henochscholeinpurpura hsp im lupus pathophysiology progressive rapidly rheum rpgn signs
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
#Small #Medium ... Large #Vessel #Size ... #Classification ... #ANCA #Differential ... #Algorithm #Ddxof
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
abnormalities SMALL ... Schonlein Purpura (IgA ... Findings by Vessel Size ... against MPO • Complement ... #rheumatology #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... : IgA nephropathy ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
based on vessel size ... can affect any size ... Small vessel vasculitis ... basement membrane; ANCA ... Medium #Large #Classification
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... infiltrate the tissue site ... Activation of complement ... histopathologic term for small ... - Cutaneous small
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
and infarcts SMALL ... Schonlein Purpura (IgA ... , IgA (cmpkx deposits ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... of small vessels ... - ANCA-associated ... dermatomyositis #Size ... #Classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Low serum C4 complement ... DDX: • ANCA (Antineutrophil ... • IgA vasculitis ... • Cutaneous small-vessel ... diagnosis #types #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... vasculitis, rheumatoid ... inflammation of the small ... RNP antibodies, Complement
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