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diagnosis management rheumatology classification differential allergy comparison hematology hypersensitivity laboratory reactions types vasculitis workup agglutinin anemia celiac champs clinicopathology coccidioidomycosis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... node), high serum IgG4 ... rheumatoid factor), ± hypocomplementemia ... with increased IgG4 ... #Related #Disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... (Granulomatous disease ... against MPO • Complement ... (Low levels mixed
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... Idiopathic • Normal Complement ... involvement: Anti-GBM Disease ... differential #diagnosis #algorithm
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... during hemolytic disease ... Type Ill - IgG and ... Complement activation ... Diagnosis #Reactions #Table
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... - Mediators: IgG ... Mechanism of Action: IgG ... reaction, Haemolytic disease ... types #allergy #table
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
- ANA > 95% (IgG ... in >90% - Low ... complement - Rare ... Evolution: Chronic disease ... sle #comparison #table
Commonly Used Diagnostic Tests for Celiac Disease Tissue transglutaminase (tTG) IgA antibodies - Most reliable noninvasive test
Tests for Celiac Disease ... negative if on low-gluten ... transglutaminase (tTG) IgG ... antibody test IgG ... Diagnosis #Workup #Table
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Disease ... Cold Agglutinin Disease ... originate from a low-grade ... Donath-Landsteiner (IgG ... temperatures by fixing complement
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Ischemic heart disease ... event, follow ACC algorithm ... : - Known CV disease ... Structural heart disease ... Orthopedic • Low
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