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diagnosis rheumatology classification differential vasculitis hypersensitivity nephrology pathophysiology reactions table acuteglomerulonephritis bergersdisease champs clinical comparison cryoglobulinemia cryoglobulins glomerular hematology hypersensitivityreaction
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... , type 1 (50%-80% ... ), type II (80-90% ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Soluble antigen - Allergen-specific ... When the specific allergen ... antigen, leading to complement ... Complement activation ... Post-streptococcal glomerulonephritis
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
lgE causes mast-cell ... antigens, leading to complement ... they activate complement ... Post-streptococcal glomerulonephritis ... #allergy #table
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... pathophysiologic causes ... staining): • Low Complement ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity ... self-antigens are the cause ... antigens are the cause ... Post-infectious glomerulonephritis ... HypersensitivityReaction #Allergy
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... , Glomerulonephritis ... against MPO • Complement
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Skin ulcers - Glomerulonephritis ... Cryoglobulins Cause ... Types: • Type ... • Low serum C4 complement
Comprehensive pathogenesis of IgA Nephropathy (i.e Berger’s Disease). IgA Nephropathy is the most common cause of
the most common cause ... of Glomerulonephritis ... - What type of Hypersensitivity ... Relationship of complement ... AcuteGlomerulonephritis #Glomerulonephritis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, pauci-immune glomerulonephritis ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic ... Mononeuropathy, Glomerulonephritis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... • Can cause TYPE ... IV RTA, TYPE I ... nephritis • Distal (Type ... acidosis • NAGMA • Glomerulonephritis
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