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diagnosis rheumatology allergy hypersensitivity reactions hematology management differential gammopathy monoclonal table vasculitis allergic biopsy champs comparison cryoglobulinemia cryoglobulins definitions disease
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis, type ... 1 (50%-80%), type ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
reactions Type ... (Anaphylaxis) Type ... II - IgG or IgM ... Complex-Mediated, 1-3 Weeks (Serum ... #Classification
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... lymph node), high serum ... IgG4 concentration ... eosinophilia, ↑ serum ... rheumatoid factor), ± hypocomplementemia
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
II - IgG or IgM ... antigen, leading to complement ... Type Ill - IgG and ... Complement activation ... #Classification
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Subtypes of Serum ... • Gamma: IgM, IgG ... Proteins #Subtypes #algorithm ... #classification ... #Types #hematology
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
dysfunction • Serum ... • Pancreas: Type ... Labs: - ↑ Serum ... - ↑ IgE, ↓ complement ... • Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
- Mediators: IgG ... Mechanism of Action: IgG ... antigens, leading to complement ... they activate complement ... allergy #table #classification
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
conjunctivitis Type ... Mediator: IgM + IgG ... Immunological Mediator: IgG ... glomerulonephritis, Serum ... #Classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
are Igs in the serum ... the presence of serum ... level • Low serum ... C4 complement level ... #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
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