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diagnosis rheumatology druginduced lupus coccidioidomycosis comparison differential dil disease fever infectiousdiseases phenotypes related sjogrens sle syndrome table valley vasculitides vasculitis
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
with response to treatment ... rheumatoid factor), ± hypocomplementemia ... + cells" Treatment ... Disease #diagnosis #management ... phenotypes #workup #treatment
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... - ↑ IgE, ↓ complement ... • Classification ... mimics excluded MANAGEMENT ... #Management #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
- ANA > 95% (IgG ... 90% - Low complement ... 80% - Low complement ... life-threatening • Treatment ... Usual therapeutic management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... Adenocarcinoma Treatment ... Rheumatology #Diagnosis #Management
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
- ANA > 95% (IgG ... 90% - Low complement ... constitutional symptoms • Treatment ... rheumatology #diagnosis #treatment ... #management
Coccidioidomycosis (Valley Fever) - Diagnosis and Management Summary WHAT? • Coccidioidomycosis due to Coccidioides immitis or Coccidioides
Diagnosis and Management ... analysis using complement ... check for IgM and IgG ... TREATMENT: Clinically ... Fever #Diagnosis #Management
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