9 results
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Injury - Ichemic hepatitis ... injury - Viral Hepatitis ... - Autoimmune ... hepatitis - Wilson ... #Hepatology #Diagnosis
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... α1-antitrypsin deficiency ... Nonalcoholic fatty liver ... #Hepatology #Cirrhosis
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
) • Advanced Liver ... , Viral hepatitis ... , Autoimmune • ... Septic shock, Obstetric ... comparison #diagnosis #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Ischemia • Autoimmune ... • Drugs • AIH ... • Alcoholic hepatitis ... Others #LFTs #Hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Hepatitis - Onset ... Possible ischemic hepatitis ... 1 antitrypsin deficiency ... #Hepatitis #Diagnosis ... #Hepatology #AIH
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis ... from subclinical disease ... Other Etiology of Hepatitis ... #Hepatitis #AIH ... #Hepatology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Liver diseases ... and hepatitis ... : Pneumonia • Autoimmune ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
HBV, EBV, VZV, hepatitis ... hepatitis, PBC, ... PSC, Viral hepatitis ... gastric tumors • Hematology ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
rheumatologic diseases ... • Prolidase deficiency ... Noninfectious hepatitis ... : • AIHA 10% • ... Erythematosus #Diagnosis #Rheumatology