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diagnosis adrenal insufficiency differential workup ai alkaline alp causes cosyntropin cushings elevation evaluation hepatology hypercortisolism laboratory pathophysiology phosphatase signs stimtest
Adrenal Insufficiency Differential Diagnosis Algorithm Clinical suspicion: Weakness, fatigue, nausea, musculoskeletal pain, dizziness, volume depletion, abdominal pain,
Differential Diagnosis Algorithm ... ) stimulation test ... - Primary adrenal ... - Secondary adrenal ... #endocrinology
Adrenal Insufficiency Diagnosis Algorithm - Evaluation of HPA Axis Response to ACTH Early am cortisol < 3
Insufficiency Diagnosis Algorithm ... OR secondary AI ... Insufficiency #Diagnosis #Algorithm ... #ACTH #Stimulation ... #Test #Endocrinology
Diagnosis Adrenal Insufficiency - Algorithm Step 1) Screening Test: 6-8AM Cortisol Level - Early morning cortisol levels
Insufficiency - Algorithm ... Differentiate primary ... vs secondary AI ... consistent with primary ... #Stimulation #Endocrinology
Primary vs Secondary Adrenal Insufficiency - Pathophysiology Primary AI = adrenal glands themselves are the problem. This
Primary vs Secondary ... be low, while ACTH ... Low ACTH leads to ... limited adrenal stimulation ... Pathophysiology #endocrinology
Adrenal Insufficiency Diagnosis Algorithm Clinical features: - Weight loss, anorexia, Weakness, fatigue, GI distress - Hypotension,
Insufficiency Diagnosis Algorithm ... skin (due to high ACTH ... stimulating melanocytes ... , only seen in PRIMARY ... #StimTest #Endocrinology
Primary Adrenal Insufficiency: • ACTH stimulation test - Synthetic ACTH does not stimulate cortisol secretion because
Primary Adrenal ... autoimmune-mediated primary ... antibody test Secondary ... - If the secondary ... diagnosis #testing #endocrinology
Adrenal Insufficiency - Differential Diagnosis Workup Algorithm Primary Adrenal Insufficiency: • Autoimmune primary adrenal insufficiency • Adrenoleukodystrophy,
Primary Adrenal ... • Autoimmune primary ... or tuberculosis Secondary ... apoplexy • Isolated ACTH-deficiency ... #endocrinology
Causes of Adrenal Insufficiency - Differential Diagnosis Algorithm ACTH-Dependent (Secondary): • Pituitary Dysfunction • Hypothalamic Dysfunction ACTH-Independent (Primary):
Differential Diagnosis Algorithm ... ACTH-Dependent ... (Secondary): • ... (Primary): • Autoimmune ... #Causes #endocrinology
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features 1) Skin • Thin, easily bruisable skin with
• Acne • If secondary ... not a feature of primary ... menstrual cycles 5) Secondary ... Imaging: 1) Primary ... signs #symptoms #endocrinology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... ) or increased stimulation ... - Drugs - Primary ... biliary Cholangitis ... #hepatology
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