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IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis - Induction, Consolidation and Maintenance Therapy

Table 2. Antifungal Treatment Recommendations
IDSA Treatment Recommendations ... for Cryptococcal ... and Maintenance Therapy ... Recommendations for Cryptococcal ... #meningitis #cryptococcus
IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Human Immunodeficiency Virus Infected Individuals
Induction therapy:
 • AmBd (0.7–1.0
IDSA Treatment Recommendations ... for Cryptococcal ... week) >1 year #Cryptococcal ... #Treatment #management ... #meningitis #cryptococcus
IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Transplant Recipients
Induction therapy:
 • liposomal AmB (3–4 mg/kg per
IDSA Treatment Recommendations ... for Cryptococcal ... year B-III #Cryptococcal ... #Treatment #management ... #meningitis #cryptococcus
Initiation of ART in HIV patients with Opportunistic Infections
 • Pulmonary TB and CD4 cell count
count >50 • CNS ... regardless of CD4 • Cryptococcal ... of starting OI treatment ... Antiretroviral #Therapy
Perianal Crohn's Disease - IBD Algorithm

 • 5-40% w perianal fistula
 • ↑ risk if colonic
Disease - IBD Algorithm ... refractory to medical therapy ... Crohns #Disease #IBDAlgorithm ... #IBD #Algorithm ... gastroenterology #management #treatment
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
anidulafungin; CAS ... fluconazole; ISA ... Aspergillus fumigatus, Cryptococcus
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
antiretroviral therapy ... antiretroviral therapy ... Antimicrobial treatment ... culture positive Cryptococcal ... lesions • CSF cryptococcal
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
antiretroviral therapy ... pleural effusions, CNS ... cavitation • Cryptococcus ... patient has known cryptococcal ... for most OI • Cryptococcal
Algorithm for the Treatment of Membranous Lupus Nephritis
Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
Algorithm for the ... Treatment of Membranous ... (MMF plus CNI) ... Lupus #Nephritis #Algorithm ... #Treatment #management
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
agent of choice; therapy ... Fluconazole CRYPTOCOCCUS ... MC: CNS CSF: • ... level, presence of cryptococcal ... CSF and serum Cryptococcal