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hematology oncology leukemia management classification dermatologic differential erythematosus globulin gpa granulomatosis hypogammaglobulinemia immunodeficiency immunology lupus lymphocytic mds myelodysplasia myelodysplastic polyangiitis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... weeks without infection ... Hepatomegaly • Skin ... #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... - Clinical Presentation ... Lymphoma Workup ... #lymphoma #diagnosis ... classification #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... pain, bleeding, infections ... bruising, bleeding, infection ... #Hematology #Oncology ... #Diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
-> increased infection ... history of recurrent infections ... disease • Infectious ... infections (Epstein-Barr ... hypogammaglobulinemia #immunology #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... arteritis Infections ... diseases • Fungal infections ... #diagnosis #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Include: • Viral infections ... gastric tumors • Hematology ... anemia • Other ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... petechiae) • Frequent infections ... Most common cytopenia ... • Parvovirus infection ... #hematology #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
fibromyalgia) • Infections ... and CNS • Headache ... Kidney disease common ... with Lupus: • Chronic ... cyclophosphamide) • Hodgkin
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