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management leukemia oncology cll differential rheumatology bronchiectasis common cvid fungal hemeonc hepatology hepatopulmonary hps hypogammaglobulinemia immunodeficiency immunology infections infectiousdiseases mycoses
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... minimal tumor burden Diagnosis ... thrombocytopenia Complications ... #oncology #hematology ... #hemeonc #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... microglobulin Treatment ... • Richter’s Syndrome ... #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• Tumor lysis syndrome ... Transformation: • Complication ... of Chronic Lymphocytic ... #Leukemia #Hematology ... #Oncology #Diagnosis
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
• Mounier-Kuhn syndrome ... bronchiectasis, sinusitis ... sinusitis • Physical ... advanced disease Complications ... mycobacteria Treatment
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
noninfectious complications ... Autoimmunity • Chronic ... Granulomatous lymphocytic ... : • Nephrotic syndrome ... hypogammaglobulinemia #immunology #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
glands: • Focal lymphocytic ... UIP, NSIP): • Lymphocytic ... primary biliary cirrhosis ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
85% • < 50% in chronic ... infection) • Chronic ... , neutropenia, cirrhosis ... count (mainly lymphocytes ... Pulmonary (60%) • Sinusitis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... elevated protein, lymphocytic ... Eosinophilia, asthma, chronic ... destructive rhinitis/sinusitis ... #Rheumatology
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
pulmonary disorder of chronic ... triad of: 1) chronic ... • Stigmata of cirrhosis ... #cirrhosis #diagnosis ... #hepatology
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