11 results
hematology hemophagocytic hlh lymphohistiocytosis treatment blood product reactions summary activation adult adultonset arthritis cardiology endocarditis fungal hemeonc infections infectiousdiseases macrophage
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Disease (AOSD) ... Life-threatening ... #Disease #AOSD ... #rheumatology #diagnosis ... #management #treatment
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... extremities during febrile ... #disease #AOSD ... #diagnosis #rheumatology ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Adult-onset Still ... erythematosus [SLE], AOSD ... ALT ↑ bilirubin level ... #Management #Hematology ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
frequently affects infants ... age, however the disease ... acute or subacute febrile ... #management #treatment ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
, ↓ Fibrinogen level ... +, Adult-onset Still ... disease, Infection ... #management #treatment ... #summary #rheumatology
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
and Management ... active ROM +/- fever ... , chills, malaise ... necrosis, Lyme disease ... 90% sensitive in pediatrics
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Generalized: • Chills ... night sweats, fever ... Differential Diagnosis ... Paradoxical emboli via ASD ... #management #cardiology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Mediated: • Febrile ... Graft Versus Host Disease ... Borrellia (Lyme disease ... #Transfusion #diagnosis ... #management #hematology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... Increased protein level ... normal glucose level ... device removal (if ... #Management #Infections
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Mediated: - Febrile ... Graft Versus Host Disease ... Borrellia (Lyme disease ... #Transfusions #diagnosis ... #management #hematology
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