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diagnosis rheumatology treatment differential hemophagocytic hlh lymphohistiocytosis aosd comparison cppd hepatology lupus sle stills summary vasculitis adult adultonset amyloid amyloidosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... juvenile idiopathic arthritis ... juvenile idiopathic arthritis ... ALT ↑ bilirubin level ... #Management #Hematology
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
Diagnosis and Management ... active ROM +/- fever ... necrosis, Lyme disease ... Workup: arthrocentesis ... 90% sensitive in pediatrics
Kawasaki Disease (KD) - Diagnosis and Management Summary Kawasaki Disease (KD) is the most common vasculitis of
Kawasaki Disease ... Diagnosis and Management ... , Tachycardia, Arthritis ... KD #vasculitis #rheumatology ... #pediatrics #diagnossi
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... connective-tissue disease ... #Rheumatic #Disease ... #laboratory #workup
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... → Excessive activation ... , ↓ Fibrinogen level ... • Autoimmune diseases ... Lymphohistiocytosis #diagnosis #management
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... Life-threatening ... low ferritin, arthritis ... #AOSD #rheumatology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... (i.e. fibromyalgia ... Malignancy (e.g. hematologic ... vein thrombosis Hematologic ... Chronic B-cell activation
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... age, however the disease ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
early evening • Arthritis ... Arthralgias or arthritis ... • If uncontrolled ... AOSD #diagnosis #rheumatology ... #management
The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
The Liver Consult ... for admission (if ... different) PMHx: - Focus ... disease work up ... Calling #Referral #Hepatology
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