9 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Systemic lupus ... erythematosus [SLE], AOSD ... ALT ↑ bilirubin level ... #Diagnosis #Management ... #Hematology #Rheumatology
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... Life-threatening ... low ferritin, arthritis ... #AOSD #rheumatology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
, inflammatory arthritis ... weight loss, and fever ... (i.e. fibromyalgia ... Malignancy (e.g. hematologic ... vein thrombosis Hematologic
Septic Arthritis - Diagnosis and Management Summary
Clinical Exam: hot, swollen, pain with passive AND active ROM
Diagnosis and Management ... active ROM +/- fever ... necrosis, Lyme disease ... Workup: arthrocentesis ... 90% sensitive in pediatrics
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... • Immunologic Workup ... • Immunologic Workup ... Evolution: Chronic disease ... #diagnosis #management
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... joint • Systemic lupus ... #Rheumatic #Disease ... #laboratory #workup
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
early evening • Arthritis ... • If uncontrolled ... #AOSD #diagnosis ... #rheumatology # ... management
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
acute rheumatic fever ... ), RA, crystal disease ... spondyloarthropathies, lupus ... Inflammatory, crystalline disease ... #approach #workup
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
H's" especially if ... Crowned Dens Syndrome ... acute neck pain, fever ... #Rheumatology # ... diagnosis #management