231 results
Pathophysiology of IgA Nephropathy (IgAN)

Dr. Muner Mohamed @MunerMohamed1

#IgA #Nephropathy #IgAN #Pathophysiology #nephrology
Pathophysiology of IgA ... Nephropathy (IgAN ... MunerMohamed1 #IgA ... #Nephropathy #IgAN
Management of adult IgA Vasculitis (Henoch-Schönlein purpura) - Treatment algorithm for the management of IgAV patients
Management of adult IgA ... management of IgAV ... Management of IgA ... TerrierBen #IgA ... #Vasculitis #IGAV
Diagnosis of IgA Vasculitis (Henoch-Schönlein Purpura) - French Vasculitis Study Group 

1) Suggestive clinical manifestations
Diagnosis of IgA ... Elevated serum IgA ... vasculitis with IgA1 ... - Dominant IgA ... with vascular IgA
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... immune response, IgA ... (GD-IgA1). ... -> Decr IgA serum ... -> adhesion of IgA
Commonly Used Diagnostic Tests for Celiac Disease

Tissue transglutaminase (tTG) IgA antibodies
 - Most reliable noninvasive test
transglutaminase (tTG) IgA ... patients with IgA ... and specificity IgA ... disease less than IgA ... specific as tTG IgA
Comprehensive pathogenesis of IgA Nephropathy (i.e Berger’s Disease). 

IgA Nephropathy is the most common cause of
pathogenesis of IgA ... IgA Nephropathy ... - Why is IgA Nephropathy ... Hypersensitivity is IgA ... complement to IgA
Celiac Disease Testing Algorithm
INDICATIONS FOR TESTING:  Nonspecific symptoms (iron-deficiency anemia, failure to thrive, fever, skin
Immunoglobulin A • tTG IgA ... • tTG IgG and ... DGP IgGa • EMA ... IgG by IFA • DGP ... IgA • HLA testing
Causes of Secondary IgA Nephropathy - Differential Diagnosis Algorithm
 • GI disorders: Celiac disease, Crohn's disease,
Causes of Secondary IgA ... Schistosomiasis • Cancers: IgA ... #Secondary #IgA
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Normal C3/C4 (IgA ... ): IgA Nephropathy
Subtypes of Serum Proteins

Pre-albumin (Transthyretin)
Albumin
Globulins
 • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transferrin • Gamma: IgM ... , IgG, IgA, RF,