97 results
Classification of COVID-19 Disease States and Potential Therapeutic Targets

Viral Response Phase -> Host Inflammatory Response Phase
Stage
Phase) Stage Ill ... immunoglobulin, IL ... -6 inhibitors, IL ... Classification #Diagnosis #Pathophysiology
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic Algorithm ... Pathophysiology ... - Pathophysiology ... consultations): - Ill-appearing ... Color #Targetoid #Algorithm
Heme Synthesis Pathway
Enzymes
1. ALA Synthase
2. ALA Dehydratase
3. Porphobilinogen deaminase
4. UP Ill Synthase
5. UP Ill Decarboxylase
6. Coproporphyrinogen
UP Ill Synthase ... UP Ill Decarboxylase ... Synthesis #Pathway #pathophysiology
Central Distribution, Febrile / Ill:
 - Viral Exanthem 
 - Lyme Disease (erythema migrans) 
Central Distribution,
Distribution, Febrile / Ill ... Afebrile, non-ill ... Afebrile / non-ill ... Afebrile / non-ill ... Papules #Rash #Algorithm
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Erythematosus (SLE ... system defects (i.e ... Interferon-a, IL ... -6, IL-10 #Systemic ... #Pathophysiology
Main causes of diffuse parenchymal lung diseases.

#differential #algorithm #diagnosis #causes #DPLD #ILD #parenchymal #lung #diseases #pulmonary
#differential #algorithm ... #causes #DPLD #ILD
Diagnostic algorithm for idiopathic pulmonary fibrosis, in part adapted from the ATS/ERS consensus statement. HRCT =
Diagnostic algorithm ... computerised tomography; ILD ... #IPF #UIP #Algorithm
Management of interstitial lung disease (ILD)-associated with systemic sclerosis (SSc)

Therapeutic indication: absolute decline in FVC >10%
lung disease (ILD ... #lungdisease #ILD ... management #treatment #algorithm
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
synthesis, e.g., IL ... -1, IL-2 Muromonab-CD3 ... Basiliximab - IL ... Suppression of IL ... #Pharmacology #Pathophysiology
Hypothermia in Sepsis - Pathophysiology
 • 20% of septic pts → HYPOTHERMIA
 • Increased mortality 62%
Hypothermia in Sepsis - Pathophysiology ... cytokines ↓TNF-α, ↓IL ... -6, ↓IL-1 3. ... cytokine response ↑IL ... Hypothermia #sepsis #pathophysiology