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rheumatology dermatology antimda5 antimda5dm antinxp2 antinxp2dm autoimmune differential management myopathy myositis pathophysiology pm polymyositis signs symptoms vasculitis
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
• Periorbital heliotrope ... (blue-purple) rash ... • Erythematous rash ... Liver biopsies show ... #dermatology #diagnosis
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... /- swelling -> Heliotrope ... Rash - Dysphagia ... #PM #Diagnosis ... Pathophysiology #Signs
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
DM with generalized ... to have typical DM ... • Periorbital heliotrope ... (blue-purple) rash ... • Erythematous rash
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Symptoms: • Gottron rash ... papules and Gottron sign ... ) • Shawl sign ... • Heliotrope • ... elevated < PM and DM
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