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Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... Idiosyncratic #differential ... #Diagnosis #Management ... #gastroenterology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Failure (ACLF) Clinical ... Drug-Induced Liver Injury ... #ACLF #Acute #Chronic ... Cirrhosis #Hepatology #gastroenterology
Central Venous Catheter site selection - Clinical Decision Aid
IJ vs Subclavian vs Supraclavicular vs Femoral by
site selection - Clinical ... and mechanical injury ... @broomedocs #Management ... #CriticalCare #
Gastric Intestinal Metaplasia (GIM)
 • GIM is a precancerous, histopathologic change characterized by replacement of normal
in response to chronic ... common trigger is chronic ... pylori) gastritis Clinical ... GIM #diagnosis #management ... #gastroenterology
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Shock - Differential ... Medications, Spinal Cord Injury ... Sophia_Hayes_MD #Shock #Differential ... #Diagnosis #criticalcare ... algorithm #treatment #management
Myocarditis 

5 Principles of
Myocarditis:
1. Build clinical suspicion
2. Decide on EMBx
3. Manage acute cardiac injury
4. Manage chronic
Build clinical suspicion ... acute cardiac injury ... Manage chronic cardiac ... myocarditis Clinical ... Myocarditis #diagnosis #management
Pancreatic cystic lesions (PCLs)
 - classified into simple retention cysts, pseudocysts and cystic neoplasms 
 -
histological and clinical ... lesions #PCLs #gastroenterology ... #diagnosis #management ... #differential
Chronic Pancreatitis

Definition: A pathologic fibroinflammatory syndrome of the pancreas in individuals with genetic, environmental, and/or other
Chronic Pancreatitis ... to parenchymal injury ... sensitivity) Clinical ... Pancreatitis #diagnosis #management ... #gastroenterology
Noninvasive Positive Pressure Ventilation (NIPPV)

Expiratory & Inspiratory Positive Airway Pressure
Both increase intrathoracic pressure, which can decrease
often w/ acute on chronic ... hair) • Risk Of Clinical ... pneumothorax. esophageal injury ... #indications #criticalcare ... #management
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - Differential ... Framework and Management ... Dermatomyositis Clinical ... Rhabdomyolysis #Differential ... #Diagnosis #Management