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diagnosis causes lactate acidosis algorithm classification clinical creatine creatinekinase dehydrogenase electrical electrocution elevation heat heatstroke hepatitis hepatology illness kinase laboratory
RHABDOMYOLYSIS • Characterized by skeletal muscle breakdown & necrosis. • Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. • Defined based
RHABDOMYOLYSIS ... • Elevated Creatine ... is 1.5 days; elevated ... marker of muscle injury ... #trauma #statins
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Kinase - Causes of Elevated ... Weakness): • RHABDOMYOLYSIS ... - Seizures: Trauma ... infarction, Acute renal injury ... #CK #differential
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Elevated levels ... of rhabdomyolysis ... days; its level elevated ... without apparent cardiac ... @DharSaty #rhabdomyolysis
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... Muscle: • Rhabdomyolysis ... thrombosis Cardiac ... Demand ischemia • Trauma ... #differential #
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... , CMV, VZV • Trauma ... specificity to elevated ... Skeletal muscle, cardiac ... Skeletal muscle, cardiac
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
Heat Stroke - Differential ... sweat Heat Injury ... normal/mildly elevated ... maintain adequate cardiac ... , Rhabdomyolysis
Toaster Electrocution Electrical Injury Primary determination of injury extent = amount of CURRENT flowing through body. VARIABLES: voltage,
type of current (AC ... may result in trauma ... (lightening) AC ... monitoring, check for rhabdomyolysis ... ECG changes, ↑ CK
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 Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... liver or renal injury ... / hypoxemia -> focus ... perfusion - Cardiac ... failure - Low cardiac
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