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hepatology management lfts algorithm alp elevation enzymes hemophagocytic hlh hodgkins lymphohistiocytosis lymphoma oncology phosphatase rheumatology transaminitis abnormal activation autoimmune causes
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Low Alkaline Phosphatase ... synthesized in: liver ... Adult form: Less ... ALP in adult population ... of Low Alkaline
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
hepatic pathology (low ... + ULN ALT) / (alkaline ... Transaminitis #diagnosis ... #differential # ... hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... Diagnosis Algorithm ... disturbance (obstructed liver ... • Liver (80%) ... #hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Biliary tree or bile flow ... abnormality vs bone ... Transaminase >> Alkaline ... Transaminitis #diagnosis ... #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
ALP, alkaline phosphatase ... aminotransferase; BMI, body ... Abnormal #Algorithm #Hepatology ... #Differential # ... Diagnosis
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Diagnosis Ferritin ... be used by the bone ... is made in the liver ... HLH or Adult Onset ... Hematologic Malignancy
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Epidemiology: young adults ... the spleen or liver ... Diagnosis of B-Symptoms ... #differential # ... hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
also observed in adults ... Splenomegaly • Low ... Hemophagocytosis in bone ... lymph node, or liver ... management #treatment #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
inflammatory disease How ... arthritis (sJIA) • Adult-onset ... thrombocytopenia • Liver ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
history • Young adults ... may be high or low ... Immunohistochemical studies (to differentiate ... anymore • Routine bone ... classification #hematology
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